KMID : 1161420200230060633
|
|
Journal of Medicinal Food 2020 Volume.23 No. 6 p.633 ~ p.640
|
|
Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity
|
|
Lee Soo-Yeon
Kim Mi-Jeong Jang Su-Bhin Lee Gyeong-Eun Hwang Soo-Yeon Kwon Young-Joo Hong Jung-Yeon Sohn Myung-Hyun Park Soo-Yeon Yoon Ho-Geun
|
|
Abstract
|
|
|
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity. Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases. Plumbagin treatment significantly suppressed transforming growth factor-¥â-induced profibrotic target-gene expression and proliferation of fibroblast cell lines. Moreover, plumbagin significantly inhibited bleomycin-induced pulmonary fibrosis in mice. Taken together, these data demonstrate the inhibitory effects of plumbagin on lung fibrosis and its promise as a therapeutic agent for IPF.
|
|
KEYWORD
|
|
histone acetyltransferase, p300, plumbagin, pulmonary fibrosis
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|